Abstract: On base oi some reasonable hypothesis and by connecting theorcli-eal inferring with experiment, a pipeline transportation mathematical model (including thixotropic-rheological model and energy loss model) of CWS has been built. Energy losses, frictional coefficient and the optimum economical pipeline diameter at different flow rate of CWS can be revealed by solving the model. Practical application of pipeline transportation of CWS has proved that this model is correct and reliable.