Abstract: Using manganese nodules as immobilized carrier, in an air-lift loop reactor the investigation on comparing immobilized carrier to disposal dye wastewater with non immobilized carrier was carried out. It is proved that with nodules as immobilized carrier to degradation organisms in dye wastewater, are effecitivity the color depriving character of immobilized microbe rely on adsorption and bio-degrading, biological oxygen demand(BOD), chemical oxygen demand(COD), suspended solid(SS) and color degree can be largely removed, and the benzene can be destroyed. The treated water can be applied to culturing microbe. It's Practicable to dispose dye wastewater with immobilized microbe.