Abstract: The orthogonal experiment method and the associated analysis of the grey theory were used to analyze the results of numerical simulation and to optimize the supporting parameters for a coal mine tunnel affected by two-mining in Yangquan mining area. The designed orthogonal experiment needs 27 numerical simulations including 13 factors with 3 levels for each one. According to the supporting parameters, tunnel stabilization and deformation in the condition of different stresses and supporting parameters were analyzed. Some criteria of tunnel stabilization and deformation to determine a corresponding local optimization scheme were computed. Based on consideration of the supporting cost and difficulty of construction comprehensively, an optimal supporting scheme for the secondary dynamic pressure tunnel was deduced by the associated analysis of the grey theory. The research results were put into use in Yangquan mining area and got the satisfied support effect.