Abstract: In order to realize domestic manufacture of a large rolling mill and reduce investment of equipment, the manufacture technology of a large strip rolling mill stand was studied considering the characteristics of a 2 250 mm hot rolling mill and a 2 130 mm cold rolling mill in Maanshan Iron and Steel Co. Ltd. Through preassembling and debugging, the manufacture precision and properties of the rolling mill stand met the demand. The results of industrial testing on 2 250 mm hot rolling sheets and 2 130 mm cold rolling sheets show that under the condition of ensuring the rolling mill's quality the investment of equipment reduces and the manufacture time shortens.