Abstract: Through the process of grade and reserve calculation, a method of dealing with voxel for visualization technology and its applications in an integrated simulation system were provided for deposits. First, in order to construct regular volume data which can satisfy the needs, original sampling data were pretreated. Second, by the means of three interpolation methods, i.e. Thiessen polygon method, distance power inverse ratio method, Kriging method, users could choose an appropriate calculation method according to the fact of mines. Then, based on regular voxel information under different spatial interpolation methods, the grade and reserve were calculated in an appointed area of orebody.