Abstract: The method to control diffusion of indoor perfume pollutants in building was studied.Production source and diffusion characteristic of perfume pollutants were discussed.The control plan was proposed that pollution sources were isolated separately and then pollutants were collected.The exhaust system was designed.The optimal flow velocity in pipeline was obtained to be 5.6-6.0 m·s^-1 based on numerical simulation.Test results proved that more than 90% of perfume pollutants were trapped and the method was an effective way to control the diffusion of perfume pollutants.