Abstract: The immune network model of Varela is the second generation network model following the Jerne's.The dynamic balance relation of T and B cells without antigen effect is described in Varela immune network model.An improved Varela's immune network model considering antigen base on Varela's immune network model was founded.Some biologic characteristics can be described by the improved Varela's immune network model to a certain extent.Then an immune controller model was constructed on base of the improvement Varela's immune network model that is independent of system object model.With a big lag model as the controlled plant,the characteristic of the immune controller was studied with simulation.The result indicates that the controller has the memory,self-learning ability,the good anti-delay and self-adapting performance.The influence of controller parameter change on the control system performance was also studied with simulation.