Abstract: By using the self-developed agglomerate desulphurization processing, the effect of two complex agglomerate reagents on removing fine slime pyrite from high sulfur coal was studied. The synergistic effect of the two reagents was also analyzed. Experiment results showed that there was an obvious synergistic effect of the two complex agglomerate reagents on the removal of pyritic sulfur. The best proportion of the two complex agglomerate reagents was A₂B₂. The desulphurization rate of 60.40% could be obtained at the best proportion, and the clean coal production rate could be up to 70.08%. It is feasible to use the proposed technique to remove pyrite from high sulfur coal, and the complex reagents have an obvious effect on the coal agglomerate.