Abstract: Aimed at the landslide possibility and influencing factors' uncertainty of high and steep slope in Changba Opencast Mine of China, five potential influencing factors of slope landslide were firstly investigated based on field investigation and monitoring data. The key factors were analyzed by means of orthogonal experiment and the key mechanism paths acting on the slope were discussed. Then the fitting function between the influencing factors and displacement was obtained by regress method. A series of rock strength parameters, their corresponding displacements and safety coefficients were computed out in limit state. In the end, the fitting functions between rock strength parameters and displacement and between safety coefficients and displacement were presented. The results show that the safety coefficients approach 1, which indicates that the slope is in unstable state and the monitoring should be enhanced.