Abstract: In order to investigate the aseismie performance of a kind of newly developed frame structure with dense grid of slender concrete columns in walls, a quasi-static test under reciprocating lateral loads was conducted for a full-scale two-storied modal frame and the experimental results were introduced. As a comparative study, the static elastoplastic push-over analyses were performed using different softwares of ABAQUS, SAP2000 and PKPM. Compared with the experimental results, the analyzed FEM models exhibited the same crack propagation patterns in walls, and the plastic hinge points also coincided with the experimental results. Finally, a capacity spectrum was obtained to evaluate the aseismic performance of the experimental model; its aseismic performance under eight-degree rare earthquake was evaluated. It is concluded that the aseismic performance of the frame structure with dense grid of concrete columns is considerably good.