Abstract: Vehicle velocity, road dust load, and dust moisture have close relationships with dust mass concentration. Based on orthogonal experiment and multiple regression statistical analysis, a calculation model of dust mass concentration in traffic was established, with a significance of 99% and a better goodness of fit. The results of significance test of regression coefficients show that the effects of the independent variables on the dependent variable are very significant, with the order of vehicle velocity, road dust load and dust moisture. The agreement of the computed results with test data indicates that the model has high reliability.