Abstract: The effect of sintering on the performance of two kinds of catalysts was analyzed under various conditions,and chemisorption characterization of catalysts was carried out to investigate the feasibility of substituting Cu-Zn catalyst for Fe-Cr catalyst in high temperature CO water-gas shift process (HTS).Results of activity evaluation experiments show that as a fresh catalyst,Cu-Zn catalyst has a higher activity than Fe-Cr catalyst,not only in the temperature range of low temperature shift (LTS),but also in the temperature range of HTS.On the other hand,sintering of Cu-Zn catalyst is obvious in the beginning stage at a relative high temperature of 450℃,but gets steady after 500 h,and in the steady stage the activity of Cu-Zn catalyst is still higher than that of Fe-Cr catalyst.The results of activity evaluation accord with those of CO chemical sorption.A CO water-gas shift process with substituting Cu-Zn catalyst for Fe-Cr catalyst was suggested in both HTS and LTS processes,in which the CO content could be removed to below 1% from the inlet content of 10%.