Abstract: Mine accident data for nearly 6 years from the work safety administration of Qinghai Province in northwestern China were studied from the two aspects of mine accident probability and mine accident death probability. The risk analysis of mine accidents in high-altitude, cold and drought areas was performed by means of the information diffusion theory. A mine accident model was built which is suitable for these areas with special requirements. The analysis model, parameters and prediction results coincide with the actual situation. It is revealed that the information diffusion theory can be applied to the risk analysis of mine accidents in high-altitude, cold and drought areas and predict the average annual probabilities of mine accidents and personnel death in the mine enterprises for technical support and policy recommendations.