Abstract: A performance-based fire-resistant design method was proposed for analyzing the fire safety of a large span and large space building. First, the temperatures of components are determined through fire scene analysis and simulation, then the stresses of components at different temperatures are calculated by software, thus which component needs fire protection can be determined. The main station building in Qingdao North Station is a complicated structure system, a large space layout, and beyond the specifications of fire safety design codes. According to the current standards it is difficult to satisfy the safety and economic requirements. The performance-based method was used to evaluate the fire safety of the main station building in Qingdao North Station, and some fire protection measures were given on the basis of the evaluation results.