Abstract: Compared to the explosion cladding method and explosion-rolling cladding method, TA1/Q345 clad plates produced by the vacuum rolling method can better meet the demands of large-scale production. A TA1 titanium alloy sheet was packed between two Q345 steel plates to obtain a composite slab. The composite slab was vacuumized to 0.1 Pa and then sealed. At temperatures of 840 to 930℃ the composite slab was rolled to a cladding plate. The mechanical properties of the cladding plate were tested, and the interracial microstructure and bonding were analyzed by scanning electron microscopy, X-ray diffraction, and micro hardness tester. In the laboratory condition, the shear strength of the cladding plate is above 159 MPa, more than the standard requirement of Class 1 clad plates. The bonding mechanical properties are excellent when the rolling temperature is 870℃. During rolling at 900℃ and 930℃ there occur phase transitions in the titanium and a great deal of intermetallics form near the interface. Too much deformation resistance difference between the titanium and the steel brings about more uncoordinated deformation and internal stress near the interface, which decrease the shear strength of the interface. The lower shear strength at 840℃ is due to the low rolling temperature, which leads to slow element diffusion near the interface.