Abstract: According to the working conditions of the hot coil box in a domestic steel 2250 hot rolling production line, the birth-death element and re-start technology of the finite element analysis software ANSYS was adopted to simulate the production rhythm of coiling, insulation and uncoiling of intermediate slabs. The interface heat transfer coefficients of intermediate slabs were determined in different heat transfer conditions. The effects of process parameters and environmental factors on the temperature of intermediate slabs in the hot coil box were analyzed on the basis of simulation data. A mathematical model of three-dimensional temperature fields was established for intermediate slabs in the hot coil box. Finally, the outlet temperature of intermediate slabs in the hot coil box was calculated, which can provide us with some feasible suggestions for hot rolling temperature control.