Abstract: Lead citrate was prepared by the reaction of lead oxide and citrate. The effects of dissolution time,dissolution temperature,sodium citrate concentration,and the addition amount of citric acid on the dissolution rate of lead citrate in sodium citrate solution were investigated. Experimental results show that,dissolution temperature,sodium citrate concentration,and the addition amount of citric acid are the main influencing factors. Increasing the dissolution temperature or the sodium citrate concentration can significantly improve the dissolution rate of lead citrate. The dissolution rate of lead citrate has a positive linear relation with the dissolution temperature,and the fitted linear equation is Y=0.76 + 0.63T. Adding citric acid can inhibit the dissolution of lead citrate.