Abstract: The base reaction of CFG pile composite foundation with non-uniform pile arrangement was numerically calculated by applying interaction analysis software that can consider the isoparametric elements of medium plates on a limited compressible foundation, and it was compared with that of uniform natural foundation and CFG pile composite foundation with uniform pile arrangement. The results show that if the piles are placed more densely at the core tube area than the external frame column area, the maximum settlement and the raft3s relative deflection are obviously smaller than those of the uniform pile arrangement. The base reaction distribution of non-uniform pile arrangement is quite different from that of uniform pile arrangement and it correlates well to the modulus of the composite earth layer:the base reaction is the largest and distributes evenly, nearly a linear distribution, within the extent of 1 time the slab thickness surrounding the core tube area; the effective transfer range of load is 2.5 times the slab thickness, and the base reaction gradually decreases within the extent from 1 time to 2.5 times the slab thickness surrounding the core tube area; the base reaction reaches minimum outside 2.5 times the slab thickness and distributes uniformly, almost following a linear distribution. On the whole, the base reaction shows a basin-shaped distribution.