Abstract: Based on seismic performance tests on frame-supported grid-mode lightweight slab structure(FSGL slab structure) specimens,the mechanical behavior of the structure was quantitatively analyzed and seismic design suggestions were put forward. The results showed that constructional columns for the both sides of an open hole compensated for strength degradation caused by the hole,improved the safety-reserved capacity of the wall,but increased the damage degree of the wall at the late stage and deteriorated the repairable capacity. The oblique frame-grid design was able to change the way of transmission-loading to make strength degradation more uniform and let the structure have a better deformation recovery ability,and this design could obviously decrease the damage degree of the wall,but the overall safety-reserved capacity was not much improved. In engineering design,the proposed initial stiffness-ratio range of the transfer layer was approximately 1.3 to 1.6. Due to an obvious decrease in stiffness-ratio of the transfer layer under loading,the initial stiffness-ratio should properly increase in the design process. The displacement and angle values between inter-layers are within the safety limits,indicating that the structure has good collapse-resistant capacity and energy dissipation performance.