Abstract: To ensure the integrity, real-time performance, confidentiality and usability of data transmission in networked control systems and improve the ability of the system against data attacks, a data transmission strategy based on the MD5 hash code, time stamp, and AES encryption algorithm was proposed. This strategy takes into account the security and real-time of data transmission of both the controlled object side and the controller side of the networked control system. And the networked predictive control based on round trip time delay was used to compensate for the effect on the system after it had been attacked by data, so that the system can be stably controlled after being attacked by some intensity of data and also achieves a better control effect, thereby improving the ability of network control systems to deal with attacks. The S100-1 training platform pipeline pressure control system is used to prove that the proposed networked predictive control system based on the secure transmission strategy has better security and anti-attack ability.