Abstract: Thick-section Al-Zn-Mg aluminum alloy extrusions are key materials for manufacturing rail transit vehicles, and stress corrosion cracking (SCC) is an important engineering application problem during the service life of these materials. The effect of sampling direction on the stress corrosion cracking behavior of Al-Zn-Mg alloys was investigated through constant load tensile stress corrosion and electrochemical tests. The microstructures of specimens were analyzed in different sampling directions both before and after stress corrosion via optical microscopy, scanning electron microscopy, and electron backscatter diffraction. Specimens with their tensile axes parallel or perpendicular to the extrusion direction of the extruded profiles were labeled as longitudinal specimens and transverse specimens, respectively. The specimens were completely immersed in a corrosive solution, a mixture of 35 g Na Cl and 1 L deionized water, with a constant unidirectional loading of 225 MPa for 360 h at 50 ± 2 ℃. The experimental results show that the transverse specimen is fractured at 315 h, whereas the longitudinal specimen does not break during the entire loading process. Thus, the transverse specimens have poor resistance to stress corrosion cracking. The corrosion current density of the longitudinal section (L-S) is0. 980 m A·cm-2, which is approximately 5 times that of the transverse section (T-S). Thus, corrosion tends to propagate along the longitudinal direction. The L-S is more susceptible to corrosion than the T-S owing to the larger misorientation difference and higher energy of the grain boundary. During the stress corrosion loading process, anodic dissolution occurs and forms corrosion pits. Then, the cooperation of the wedge force produced by the accumulation of corrosion products and constant load causes the crack to propagate along the grain boundary. Intergranular corrosion of the two types of samples is obvious under all immersion corrosion conditions. Different specimens exhibit the tendency to undergo stress corrosion cracking.