Abstract: Porous media are widely found in underground rocks, biomimetic, and engineering materials. However, the current flow theory of fluids (liquid and gas, etc.) is incomplete to study flows in small and complex pores, thus a new theory is urgently needed for studying a large number of fluid flows in porous media. The theory of meso-scale flow in porous media is a “mysterious key” to unlock the flow of nano-micron porous media. At present, a large number of fluid flow problems need an immediate solution in porous media such as shale oil and gas development, soil seepage, human capillary network, and carbon nanotube (CNT). With the advancement of world petroleum engineering technology, unconventional oil and gas reservoirs have become the main areas of development in the petroleum industry. There are a large number of nano-scale pores in unconventional oil and gas reservoirs, and the existing macro-statistical methods of Darcy and non-Darcy percolation cannot reveal the nonlinear flow mechanism and effective production mechanism of fluid in mesopores. Thus, it is urgent to carry out theoretical research on meso-flow in porous media to provide a theoretical basis for unconventional oil and gas development. This paper summarizes the research results in this area, including those of the authors. The current research status of fine and meso flow in porous media is summarized from three aspects: (1) theoretical analysis, (2) experimental research, and (3) numerical model, focusing on key issues such as the relationship and characterization of meso-scale fluid flow interface and micro-mechanical properties, meso–macro network simulation, meso-scale fluid (oil/water, gas/water) flow, meso-dynamic mechanism, and mathematical models. On this basis, the importance of the research on the interface effect and meso-mechanical characteristics of fine and micro-scale fluid flow, the nonlinear flow mechanism of the fine and meso-scale fluids, the construction of a mathematical model reflecting the meso-scale flow under the action of micro-forces, and the formation of a network simulation method are introduced. The study provides certain guiding significance for unconventional oil and gas development processes, revealing the meso-causes affecting flow, clarifying the production mechanism under different conditions, and promoting further development of the discipline of seepage mechanics.