Abstract: The innovation in the direction of scientific research is a major issue in the development of science and technology, which involves variety of philosophy and methodology, and it is important and necessary for scientists and engineers. Based on the interpretation of “innovation”, combined with the author’s understanding and experience, this paper summarizes a 32 words formula for the scientific and technological innovation of engineering, and proposed the specific methods for scientific research innovation, such as “first principle, demand guidance, positive extrapolation, interdisciplinary, reverse thinking, node exhaustion”, as well as the concepts of model tree, node method and so on. The typical application of these methods is demonstrated by taking oil and gas drilling technology as an example.